Call for Papers for Special issue on central and peripheral peptides in the control of energy balance
• 大类 : 医学 - 3区
• 小类 : 生化与分子生物学 - 4区
• 小类 : 内分泌学与代谢 - 4区
• 小类 : 药学 - 3区
Since the original landmark discovery by Starling and Bayliss (1902) it has been recognized that chemicals convey information between cells of multicellular organisms and play a critical role in the control of physiological function. The basic machinery required for protein synthesis, post-translational modification, and secretion is ubiquitously expressed resulting in peptides being the largest and most diverse class of signaling molecules. Over the last decades there has been numerous peptides identified both in peripheral organs and in the brain that modulate energy homeostasis. This research focus has been in large part a response to the obesity epidemic.
The gastrointestinal tract is the largest endocrine organ in the body. Peptide hormones released from the gut function to optimize digestion and absorption of nutrients but also serve an essential role in neuroendocrine control of energy balance. The majority of these hormones act to terminate a meal either by activation of the gut-brain axis or by acting directly on neurons of the brain by means of the circulation. Many of the same peptides have also been identified in the brain where they act as neuropeptide transmitters that also control food intake. Interestingly central and peripheral actions of peptides can have opposing effects on food intake and energy intake. The majority of these peptides acutely control food intake, but some peptide hormones released from other peripheral organs, such as insulin, provide information about day-to-day fluctuations of energy status and help maintain body weight over longer periods of time.
In this special issue, we will select articles that either provide a critical review of current understanding of individual peptides with roles in either short-term or long-term control of food intake, and/or original research articles that advance our knowledge of this field. The goal will be to gather information to collect the most up to date information to better understand peptidergic control of food intake. Of particular interest will be manuscripts that address (a) peptides that control feeding behavior; (b) the site actions of these peptides; (c) their role in energy and metabolic homeostasis; (d) how peptide signaling is disrupted in obesity; and (e) whether they can be targeted for therapeutic treatment.