Call for Papers: Status and future perspectives of Auger (Low Energy Electrons) Emitting Radionuclides for Targeted Radionuclide Therapy
• 大类 : 医学 - 3区
• 小类 : 核医学 - 3区
We are delighted to present this special issue of the Journal of Nuclear Medicine and Biology dedicated to “Status and future perspectives of Auger (Low Energy Electrons) Emitting Radionuclides for Targeted Radionuclide Therapy”.
Auger (Low energy electron) emitting radionuclides (including Coster-Kronig and conversion electrons) represent great potential for Targeted Radionuclide Therapy (TRT) of cancer. Combination of high Linear Energy Transfer (LET) and emission of multiple electrons per decay allow very selective delivery of therapeutic doses (cell killing) on the sub cellular level. This causes maximal damage to the targeted cells and minimizes harm to neighboring healthy cells. However, currently the therapeutic potential of Auger emitters is not optimized, in our opinion, due to the unavailability of most suitable Auger emitters and challenges with delivery of them into/close to the cell nucleus.
In this special issue we would like to present a synthesis of expert opinions on suitable Auger emitting radionuclides, their production andin vivodelivery strategies. A theoretical and experimental overview of the physics of low energy electrons and their potential for use in nuclear medicine will be important to further match the physical properties of Auger emitters with biological targeting mechanisms. Suitable delivery systems and radiosensitive targets in the cell are key aspects in the development of new TRT radiopharmaceuticals and will be discussed. And finally, pre-clinical and clinical dosimetry considerations on the cellular level (microdosimetry) for personalized medicine will be important for future design of TRT radiopharmaceuticals with Auger emitters or combination of Auger emitters with other therapeutic emissions (alpha and β-).
Our goal with this special issue is provide the scientific community with current updates in the field of Auger therapy and initiate discussion on the future directions.