Eva Wolf (Johannes Gutenberg-University of Mainz), Achim Kramer (Charité - Universitätsmedizin Berlin) and Journal of Molecular Biology are organizing a special issue focused on ”Molecular Mechanisms underlying circadian regulation“.
The 24 h periodicity of circadian clocks is generated by an intricate interplay of multiple molecular processes that are regulated in time and space. These include daily changing clock protein interactions, the day time-dependent regulation of clock protein function, activity or stability by posttranslational modifications (e.g. phosphorylation, acetylation, ubiquitination), cellular shuttling of clock proteins between the cytosol and the nucleus and circadian gene regulation (transcriptional, epigenetic, posttranscriptional).
Topics that the Editors plan to address in this issue are:
The role of these molecular processes across species
Entrainment mechanisms to light and temperature as well as mechanisms underlying temperature compensation that were recently elucidated.
Molecular links between cellular and tissue clock
Molecular connections of the circadian clock to the cell cycle and to essential physiological processes