Special Issue: The Intersection of Inflammation and Metabolism in Neuropsychiatric Disorders
• 大类 : 医学 - 2区
• 小类 : 免疫学 - 2区
• 小类 : 神经科学 - 2区
Amassing evidence has described a bidirectional relationship between inflammation and metabolic dysfunction that not only contributes to risk for major medical illnesses, but also likely affects the brain to contribute to neuropsychiatric symptoms. Indeed, a number of patients afflicted with neurologic and/or psychiatric illnesses exhibit signs of increased inflammation that is often co-morbid with high body mass index (BMI) and/or evidence of metabolic disturbances such as dyslipidemia or insulin resistance. In addition, high peripheral or central levels of inflammatory markers and/or high BMI has been associated with poor treatment outcomes in psychiatric/neurologic patients. Obesity and metabolic disturbances have risen to epidemic rates, and neuropsychiatric illnesses such as depression are considered to be some of the largest contributors to global disability. Therefore, a more refined understanding of the respective contributions of inflammation and metabolism to symptoms of neuropsychiatric illness will provide opportunities for novel treatments and preventative strategies. This Special Issue will highlight bidirectional relationships between inflammation and metabolism and their role in the pathophysiology and treatment of psychiatric and neurologic disorders, as well as in behavioral symptoms that are associated with medical illnesses and their treatments.
Specifically, this issue of Brain, Behavior and Immunity solicits original research or review articles on topics including, but not restricted to, the role of immune and metabolic interactions in cognition, reward and emotional processing; depression, fatigue or neurodegenerative disease; the influence of circadian changes, diet or exercise; and relation to medical illnesses such as cardiovascular disease, cancer or HIV. Research related to metabolism may be broadly defined (e.g. biomarkers and processes related to metabolic disorders; interventions or lifestyle factors such as diet and exercise; cellular metabolism and mitochondrial function), and all manuscripts should include measurement of (or discussion of for reviews) at least one aspect of inflammation or the immune system.