Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Call for paper for the special issue: NanoGeneto and Genomics
• 大类 : 生物 - 3区
• 小类 : 生物工程与应用微生物 - 4区
• 小类 : 遗传学 - 4区
• 小类 : 毒理学 - 4区
Application of nanomaterials in a variety of fields and their increasing use in healthcare andconsumer products pose serious concerns about their environmental and human health impact. The genotoxicity testing of nanomaterials has gained increasing importance in recent years. DNA damage (strand breaks,altered bases), chromosomal damage (micronuclei), altered DNA repair signalling pathways, and disturbed epigenetic mechanisms are some of the outcomes observed following nanomaterial exposure. Nevertheless, experts in the field have been recognizing that nanomaterials possess special features that make them challenging from a safety assessment point of view, Critical factors that impact the assessments have been identified and include: lack of guidance and harmonised protocols for physicochemical characterization and preparation of nanomaterials for exposure (dispersion method), choice of the dose metrics and selection of realistic and meaningful concentrations to be tested, selection of mechanisms-relevant assays, consideration of assay interference, and inclusion of appropriate reference and benchmark controls, .
This Special Issue is intended to provide an overview of the current state of the art, challenges and future directionsof the genotoxicity and toxicogenomics assessment of nanomaterials. Manuscripts on the following topics (but not limited to) are welcome: i) Relationship between nanomaterials physicochemical properties (size, shape, surface chemistry, solubility, etc.) and genotoxic or genomics responses; ii) Realistic and predictive models for genotoxicity testing of nanomaterials; iii) Novel or improved protocols to conduct nanomaterialsgenotoxicity studies and iv) Recent tools and approaches (Omics, computational methods, grouping, read-across, etc.) to improve the understanding of nanomaterials genotoxicity.