Blood-CNS and Blood-Nerve Barriers in Health and Diseases and Potential Therapy
• 大类 : 医学 - 2区
• 小类 : 神经科学 - 2区
Physical barriers exist between the blood and central nervous system (CNS) (e.g., blood-brain barrier, blood-CSF barrier, and blood-spinal cord barrier) and the blood and peripheral nervous system (PNS) (e.g., blood-nerve barrier). There is increased recognition of blood-CNS barrier disruption in CNS diseases (e.g., multiple sclerosis, brain tumors, CNS trauma and infections, and stroke) and blood-nerve barrier disruption in PNS disorders (e.g., Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy) in patients. Barrier disruption is accompanied by increased inflammation and a cascade of harmful events that eventually lead to compromised tissue and long-term disability. Thus, biological markers, which can diagnose different stages of barrier damage, can be instrumental in treating neurovascular, neuroinflammatory, and neurodegenerative diseases in the clinical setting. Treatment with therapies (pharmacological approaches, cell therapy, and gene therapy) that target early-phase blood-CNS/nerve barrier injury may benefit patients by ameliorating further damage and subsequently improving long-term outcomes. For example, stem cells play vital roles in CNS homeostasis and can exhibit a broad repertoire of potentially therapeutic actions following barrier injury. Moreover, strategies that can enhance drug delivery across these barriers into CNS and PNS have broad clinical applicability. This Call for Papers will focus on the blood-CNS/nerve barrier in health and disease, including but not limited to, biomarkers, pharmacological approaches and cell and gene therapy as promising treatments for blood-CNS/nerve barrier injury, and strategies to manipulate these barriers for enhanced drug delivery (including cellular therapies).