Call for Papers: Special Issue of Neurotoxicology and Teratology - Sex Differences in Neurotoxic Effects
• 大类 : 医学 - 3区
• 小类 : 神经科学 - 4区
• 小类 : 毒理学 - 3区
Increasingly, the field of developmental neurotoxicology has found differential sensitivity of female and male offspring to gestational neurotoxic exposures. In addition, there are typical sex differences in neurobehavioral function that have been found to be diminished or reversed by developmental neurotoxic exposure. A few years ago, Clayton and Collins (2014, Nature, 509:282-283) published a landmark article stating the rationale and requirement for the study of both females and males in all NIH-sponsored studies, unless there is a cogent rationale not to do so. This is an enlightened approach as exclusion of either sex ignores effects on approximately half of the population and there is an abundant literature that sex differences are quite often biologically important. When studying the outcome of toxicant exposures during gestation, there are always female and male offspring, so the field of teratology has studied both sexes throughout its history. Thus, we have an abundant literature concerning sex differences throughout teratological research, particularly concerning differences between males and females in response to prenatal and neonatal toxicant exposure. Equally important, however, are sex differences in toxicant effects on neurobehavioral function later in development, including childhood, adolescence, and adulthood.
Accordingly, Neurotoxicology and Teratology is organizing a Special Issue on the theme of “Sex Differences in Neurotoxic Effects” of exposure throughout the lifespan to environmental toxicants, drugs of abuse, and therapeutic drugs. We invite all researchers in the field of neurotoxicology to contribute primary data-driven reports or critical review articles. Submissions may include prospective/retrospective human studies or empirical in vivo or in vitro studies using laboratory animals or cell culture systems.
The following are examples of relevant topics for the Special Issue:
Neurotoxic effects on reproductive behaviors in males vs. females
Developmental windows of vulnerability to differential neurotoxic effects between sexes
Epidemiological findings of sex differences in neurotoxicity
Sex differences in neurocognitive effects of toxicant exposure
Neural and/or endocrine mechanisms mediating sex differences in the behavioral effects of toxicant exposure