Special issue - Animal models of neurodevelopmental disorders: new insights from bench to bedside Guest Editors: Michela Fagiolini and Yuri Bozzi
• 大类 : 医学 - 3区
• 小类 : 神经科学 - 3区
In the last 15 years, a big effort has been made to investigate the neurobiological basis of neurodevelopmental disorders such as autism, schizophrenia, and their comorbidities. Studies performed in animal models are significantly contributing to formulate working hypotheses about the onset, progression and treatment of these diseases. The generation of mutant animals bearing specific mutations associated to neurodevelopmental disorders, together with the recent development of brain organoids, has allowed a better understanding of the molecular and cellular mechanisms of neural development that are disrupted in these diseases. Moreover, the generation of neurons from human induced pluripotent stem cells has provided a valid tool to pharmacologically modulate developmental processses and to test novel potential drug targets.
The goal of this Special Issue is to give a systematic overview on the recent advances in the field ofin vivoandin vitromodels of neurodevelopmental disorders, through the publication of both original research reports and reviews.
If you would like to submit your article to be considered for publication in this Special Issue, please do so athttps://ees.elsevier.com/nscand select the article type “SI: Models of Neurodevelopmental disorders” from the drop down menu.