Special Issue: Vulnerability and protective factors for inflammation-associated somatoform and mental disorders
• 大类 : 医学 - 2区
• 小类 : 免疫学 - 2区
• 小类 : 神经科学 - 2区
Recent research points to immune processes playing a part in the development and maintenance of various somatoform and mental disorders, including chronic pain, chronic fatigue, depression, anxiety, and psychosis. Although immune alterations and inflammatory components contribute to disease pathophysiology, they may not be sufficient to induce the development of these diseases on their own. Not all individuals with a heightened inflammatory activity will develop one of these disorders, and some individuals with these disorders show no changes in immune parameters. This suggests the involvement of additional factors that interact with the immune system to cause vulnerability to, or a protection against, somatoform and mental disorders. This increased or decreased vulnerability to inflammation-associated pain, fatigue and mood changes is in fact reflected in experimental models of inflammation, in which a large inter-individual variability is observed. Recent experimental studies have highlighted the moderating role of sex, sleep and pre-existent mood state in inflammation-induced behavioral changes. A “second hit” model has also been proposed for the development or exacerbation of inflammation-driven disorders, where a first inflammatory challenge primes immunoreactive compartments of the organisms, leading to stronger effects at subsequent challenges.
This special issue of Brain, Behavior and Immunity welcomes articles aiming at investigating and characterizing predictors and moderators of inflammation-associated behaviors, including, but not restricted to, pain, fatigue and mood alterations, and their underlying mechanisms. Original research studies that include both biological sexes are strongly encouraged, and the inclusion of only one sex will need to be clearly justified.