Recent advances in Natural Products Biotechnology: from Plants to Pharmacy Shelf
• 大类 : 工程技术 - 1区
• 小类 : 生物工程与应用微生物 - 1区
Since time immemorial plants have been exploited to feed people and produce beverages, but also to provide essential materials for writing, coloring, hunting and even for use in indigenous ceremonies. Moreover, plants accumulate a broad spectrum of molecules, some of which have rich pharmacological applications. Nowadays, it is estimated that the turnover of the most important commercially relevant phyto-pharmaceuticals is valued at over $25 billion per year in the USA alone (Science, 2012, 336: 1658). Paclitaxel (antineoplastic), artemisinin (antimalarial) and galanthamine (reversible cholinesterase inhibitor), among others, are good examples in this direction and amongst the blockbuster drugs/APIs worldwide.
At the same time a major challenge with the commercial supply of plant-derived molecules is their limited availability. In general, secondary metabolites account for via natural harvest is labor- and time-consuming, and could create serious ecological problems. The continuously increasing demand for therapeutic molecules, produced by ever greener processes, along with dramatic reductions in natural diversity, are the driving efforts to develop alternative approaches for sustainable production of phyto-pharmaceuticals (i.e. “green cell factories” concept). Numerous proof-of-concept studies have illustrated the feasibility of scaling up plant cell/tissue-based processes, while keeping their biosynthetic potential, hence several commercial processes have been developed so far.
This Special issue of Biotechnology Advances is designed to accommodate selected papers, to be presented at the International Conference on Natural Products Utilization: from Plants to Pharmacy Shelf (ICNPU), which fit to the journal aims and scope. The ICNPU is recognized as a premier scientific meeting in the field of natural products chemical, pharmacology and biotechnology with a wide range of audients from all over the world. The ICNPU-2019 attendees are encouraged to propose an article on a subject relevant to the journal’s focus. Please, kindly send a synopsis and CV to the Guest Editors (Rengasamy@enzymeinhibitors.co.in and firstname.lastname@example.org). The publication is by invitation only.
Invited authors have to submit their manuscripts online through the Elsevier Editorial System (https://ees.elsevier.com/jba/default.asp) no later than 01 June 2019.