Translational Use of In Vitro- and In Silico-Based Developmental Toxicity Systems for Human Health Assessment
摘要截稿:
全文截稿: 2019-07-01
影响因子: 3.121
期刊难度:
CCF分类: 无
中科院JCR分区:
• 大类 : 医学 - 4区
• 小类 : 生殖生物学 - 4区
• 小类 : 毒理学 - 4区
Overview
To assess the vast chemical space to which pregnant mothers are exposed, an integrated framework of multiple approaches, consisting ofin vitro– andin silico–based models, are needed to predict the complexity of human prenatal developmental toxicity. Global efforts are being made by multidisciplinary scientists across academia, industry and government, to develop these tools, and equally of importance, are compiling databases of legacyin vivotesting records and human chemical biomonitoring data for approach comparisons and to bridge towards risk assessment applications. An example of this includes the Integrated Approaches to Testing and Assessment (IATA) developed within the Organisation for Economic Co-operation and Development (OECD). This concept focuses on following an integrative approach to aggregate data of diverse forms (e.g.,QSARs, read-across, toxicogenomics,in vitro, andin vivo), to answer a specific question in a regulatory context. We are soliciting publications focused on translation of these approaches to risk assessment and reduce data gaps, with focus areas on exposure, hazard assessment, and risk. Specifically, articles may emphasize using a battery of approaches, anchoringin vitrodata toin vivoeffect, regulatory use cases, risk assessment frameworks, prenatal developmental toxicity focused databases, pregnant mother/fetal exposome monitoring, andin silicomodeling for broad chemical evaluation. Types of analyses may include (but are not limited to), adverse outcome pathways (AOPs), pharmacologically-based toxicokinetic modeling (PBTK), non-mammalian whole animal models, embryonic stem cells, QSAR modeling, read-across, toxicogenomics, high-throughput screening (HTS), high-content screening (HCS), and plasma concentration monitoringin vivo.