Special Issue on "Intrinsically Disordered Proteins: Amyloid Formation and Phase Separation"
• 大类 : 生物 - 3区
• 小类 : 生化与分子生物学 - 3区
• 小类 : 生物物理 - 3区
Intrinsically disordered proteins (IDPs) are emerging class of proteins that challenge the traditional structure-function paradigm. IDPs are involved in a wide range of physiological function and disease. The disorder-to-function relationships are poorly understood. An increasing body of work suggests many of the cellular functions are accomplished by the formation of binding-induced folded states or membrane-less organelles comprising liquid droplets. Additionally, dysfunction of many IDPs is associated with a range of deadly amyloid-related diseases. Recent studies have indicated that phase separation of IDPs can also promote aberrant protein aggregation that causes a variety of human diseases such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s disease and frontotemporal dementias. The BBA Proteins and Proteomics special issue on "Intrinsically Disordered Proteins: Amyloid Formation and Phase Separation" will capture the burgeoning progress on this fascinating class of proteins using multidisciplinary tools and concepts.