Dietary compounds have a significant impact on human health and for natural treatment of diseases. The striking aspect of their role is their specific function on immune cells such as myeloid cells or macrophage, granulocytes and T/B cells, and subsequently their ability to modulate the adaptive and innate immune response. Dietary compounds might play a significant role in immunomodulation whether via its activation or inhibition. Many food components have been reported to cause immunomodulation such as vitamins, polyphenols, traditional Chinese medicine, carotenoids, probiotics, indole 3 carbinol, long chain fatty acids, as well as many bioactive foods such as alcohol, nitrosamines, aflatoxin, to name a few. The dietary compounds effect on the immune system, whether beneficiary via prevention of disease development and/or progression, or harmful via immunotoxicity or immune response inhibition, have been shown with many diseases like cancer, obesity, heart diseases, liver diseases, diabetes mellites, and many other diseases.
This issue is aimed to mainly invite studies that show either development or reversal of clear end-point tissue injuries, with proposed mechanism(s). Advanced in vivo, translational, and clinical intervention studies are particularly welcomed. Advanced in-vitro studies are also considered unless they are preliminary in nature. i.e. just show effects on immune cells or immune response.
In this special issue, we aim to address the following topics:
- The impact of dietary compounds on disease process via immune system modulation whether alone or in combination with other risk factors such as age, environmental stressors, genetic abnormalities, etc.
- Identifying new mechanism(s) or expanding on existing knowledge for dietary compounds-induced immunomodulation for various diseases.
- Identifying new immunological biomarker(s) for tissue injuries and/or diseases or tissue recovery in response to dietary compounds via immune system modulation.
- Role of dietary compounds on inflammatory pathways in vivo and in vitro linked to immunomodulation.