Call for Papers - Mass Spectrometric Analysis of Lipids
摘要截稿:
全文截稿: 2018-09-30
影响因子: 2.094
期刊难度:
CCF分类: 无
中科院JCR分区:
• 大类 : 生物学 - 4区
• 小类 : 生化与分子生物学 - 4区
• 小类 : 生物物理 - 4区
Overview
Our technologies have extended our senses so that we can peer into realms previously unimagined. Accordingly, the complexity and intricacy of lipids is finally emerging into the collective view thanks in great part to advances in mass spectrometry (MS), which enabled lipidomic cataloging of even minor lipid species, their metabolites, and fatty acid variability. Prior to MS lipidomic analysis, it was impractical to investigate fatty acid variations to the extent that is necessary to characterize the many tissues, cell types and pathological variations. Early MS studies enabled the analysis of more abundant lipid components but most techniques did not have sufficient sensitivity to detect low abundance lipids, such as the phosphoinositides that have more focused functions in cellular membrane organization and intra and extracellular signaling. Some of the most potent signals are also the lowest in abundance and the briefest in existence, posing unique analytical challenges. As MS technology evolves and diversifies, aberrant lipids and their metabolites are being linked to a growing tally of pathologies, opening new possibilities for therapeutic intervention. Challenges remain in differentiating structural isomers and isobaric compounds. We still sacrifice sensitivity for high mass accuracy and vice versa. The reactivity of fatty acid double bonds still complicates lipid extraction and analysis. In situ MS is helping us identify lipids in cellular context, but greater sensitivity is needed for this approach to reach its full potential. In this special issue, we invite papers that address these challenges in lipidomic analysis, broaden our perspective of the “lipidome”, or report novel biological applications of modern lipidomics methodologies. We welcome original contributions and reviews.