Call for Papers: Special issue - SNARE proteins: a long journey of science in brain physiology and pathology - from molecular to functional studies
• 大类 : 医学 - 3区
• 小类 : 神经科学 - 3区
The SNARE proteins regulate fundamental processes at the synapse. Besides controlling exocytotic release of neurotransmitters, tSNAREs in particular modulate presynaptic voltage-gated calcium channels and thus regulate intracellular calcium dynamics and neuronal excitability. More recent studies demonstrated that SNAREs also control postsynaptic receptor trafficking, spine morphogenesis and plasticity, indicating that SNARE dysfunctions may affect not only presynaptic but also postsynaptic physiology. Among SNAREs, SNAP-25 gene associates with distinct brain diseases, including Attention Deficit Hyperactivity Disorder (ADHD), schizophrenia, bipolar disorder, and also intractable epilepsy, severe encephalopathy and intellectual disability, acting therefore as a shared biological substrate among different brain diseases. Also, mislocalization of syntaxin-1 has been described in epileptic encephalopathy, while defective SNARE function, resulting in the depletion of synaptic vesicles, has been found to induce degeneration of the synaptic terminals.
The goal of this special issue is to summarize the current state of the art in the role of SNARE proteins in the presynaptic and postsynaptic compartments, and their involvement in brain physiology and pathology through original research reports and reviews to foster continued advancement of this field.
If you would like to submit your article to be considered for publication in this special issue, please do so at https://ees.elsevier.com/nsc and select the article type “SI: SNARE proteins” from the drop down menu.