The 2019 IEEE Symposium on Immune Computation (IEEE IComputation 2019) is a part of the IEEE Symposium Series of Computational Intelligence (IEEE SSCI 2019). Immune Computation is a fast developing research area in the computational intelligence community, inspired by the information processing mechanism of biological immune system. Many of these algorithms are built on solid theoretical foundations, through understanding mathematical models and computational simulation of aspects of the immune system. The scope of this research area ranges from modeling to simulation of the immune system, to the development of novel engineering solutions to complex problems, and bridges several disciplines to provide new insights into immunology, computer science, mathematics and engineering. The aims of this symposium are: (1) to present the state-of-the-art research on immune computation; (2) to provide a forum to disseminate their recent advances and views on future perspectives in the field; (3) to offer new conceptual models for understanding the dynamics that underlie the immune system, and (4) to provide a unique event where computer scientists, engineers, immunologists, biologists, physicists, etc., may compare to each other their expertises in an interdisciplinary vision.